Autologous platelet concentrates (APCs) have emerged as a promising adjunct in periodontal regeneration, offering an innovative approach to enhance tissue healing and regeneration. These biomaterials, derived from the patient's own blood, are rich in growth factors that promote cell proliferation, angiogenesis, and tissue repair, positioning them as a valuable tool in periodontal therapy. This review aims to explore the current evidence surrounding APCs, including platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and advanced formulations like concentrated growth factors (CGF), and their application in periodontal regeneration. We summarize the mechanisms by which APCs facilitate periodontal tissue healing, highlighting their clinical outcomes in treating periodontal defects such as intrabony defects, furcation lesions, and gingival recession. Furthermore, this article addresses the advantages, limitations, and potential complications associated with APC use, along with comparisons to conventional regenerative techniques. Lastly, we present insights into the future of APCs in periodontal therapy, including emerging technologies, combination therapies, and areas for future research. As the understanding of APC biology advances, their integration into periodontal regeneration protocols is likely to revolutionize the field, offering more predictable and enhanced outcomes for patients.
Keywords: Autologous platelet concentrates, Periodontal regeneration, Tissue healing, Growth factors
