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- DOI 10.18231/j.jdp.2025.025
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Unveiling acute myeloid leukemia through gingival enlargement: A case report
Gingival enlargement might be result from many conditions like local irritation, mouth breathing drug consumption, leukemias, Wegner’s granulomatosis, sarcoidoisis etc. The consistency could be fibrotic, inflammatory or mixed. Such oral manifestation like gingival enlargement might be key factor to early diagnose and prompt treatment of fatal cases. Here is a case report of 30-year-old female who was suffering from slow, progressive gingival enlargement with lots of discomfort while chewing and speaking and later diagnosed with acute myeloid leukemia (AMLs). Acute myeloid leukemia is aggressive hematopoietic neoplasm shows high morbidity if left untreated could lead to death. So, there is crucial role of dentist when commencing the deadly disease like leukemia.
Keywords: Gingival enlargement, Acute myeloid leukemia, Monoblasts, leucocytosis, Monocytic differentiation.
References
- Omura GA. Acute leukemias. In: Greenberg MS, Garfunkel A, editors. Oral Medicine: Burket’s. 9th ed. Philadelphia: Lippincott Raven; 1999:510–30.
- Rywlin AM. Hemopoietic system: reticuloendothelial, spleen, lymph nodes, bone marrow and blood. In: Cotran RS, Kumar V, Collins T, editors. Robbins Pathologic Basis of Disease. 6th ed. Philadelphia: WB Saunders; 1999:1257–71.
- Collins FS, Sausville EA, Findberg R. Neoplastic disorders. In: Fauci AS, Kasper DL, Hauser SL, editors. Harrison’s Principles of Internal Medicine. 20th edn. New York: McGraw Hill; 2018:491–
- Wray D, Dagg JH. Diseases of the blood and blood forming organs; oral manifestations of systemic disease. In: Seymour GJ, editor. Diseases of the Oral Tissues. New York: WB Saunders; 1983:260.
- Mackie MJ, Ludlam CA, Haynes AP. Leukemias and myelodysplasia. In: Davidson AM, editor. Davidson’s Principles and Practice of Medicine. 18th ed. Edinburgh: Churchill Livingstone; 1999:737–800.
- Shafer WG, Hine MK, Levy BM. Diseases of blood forming organs. In: Shafer WG, Hine MK, Levy BM, editors. A Textbook of Oral Pathology. 4th ed. Philadelphia: WB Saunders; 1983:719–59.
- Dreizen S, Kaugars G, Silverman S Jr. The oral manifestations of leukemia. Oral Surg Oral Med Oral Pathol. 1968;26(3):278–91.
- Sonis ST, Fazio R, Fang L. Hematologic malignancies. In: Nutting CM, editor. Principles and Practice of Oral Medicine. 2nd ed. Philadelphia: Saunders; 2005:262.
- Walter JB, Israel MS. Disorders of the blood: white cells. In: General Pathology. 7th ed. Edinburgh: Churchill Livingstone; 1980:867–79.
- Greenberg MS, Glick M. Periodontal and mucosal manifestations of systemic disease. In: Dental Management of the Medically Compromised Patient. 8th ed. St Louis: Elsevier; 2012.
- Rohatiner AZS, Slevin ML, Tate T. Medical oncology. In: Walker R, editor. Clinical Medicine. 4th ed. Edinburgh: Churchill Livingstone; 2002:426–45.
- David Wray, Dagg JH. Oral periodontal management in leukemia. Saunders Dental; 1983.
- Demirer S, Ozdemir H, Sencan M, Marakoglu I. Gingival hyperplasia as an early diagnostic oral manifestation in acute monocytic leukemia: A case report. Eur J Dent. 2007;1(2):111–4.
- Bressman E, Decter JA, Chasens AI, Sackler RS. Acute myeloblastic leukemia with oral manifestations: Report of a case. Oral Surg Oral Med Oral Pathol. 1982;54(4):401–3.
- Chavan M, Subramaniam A, Jhaveri H, Khedkar S, Durkar S, Agarwal A. Acute myeloid leukemia: A case report with palatal and lingual gingival alterations. Braz J Oral Sci. 2010;9(1):67–9.
- Francisconi CF, Caldas RJ, Oliveira Martins LJ, Fischer Rubira CM, da Silva Santos PS. Leukemic oral manifestations and their management. Asian Pac J Cancer Prev. 2016;17(3):911–5.
- Mays JW, Sarmadi M, Moutsopoulos NM. Oral manifestations of systemic autoimmune and inflammatory diseases: Diagnosis and clinical management. J Evid Based Dent Pract. 2012;12(3):265–82.
- Orbak R, Orbak Z. Oral condition of patients with leukemia and lymphoma. J Nihon Univ Sch Dent. 1997;39(2):67–70.
- Blumenreich MS. The white blood cell and differential count. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd ed. Boston: Butterworth Heinemann; 1990. p. 724–7.
- Fernandes KS, Gallottini M, Castro T, Amanto MF, Lago JS, Silva PN. Gingival leukemic infiltration as the first manifestation of acute myeloid leukemia. Spec Care Dent. 2018;38(3):160–2.
- Adisen MZ, Yilmaz S, Misrilioglu M. Diagnosis of acute myeloid leukemia in dental hospital: Report of a case with severe gingival hypertrophy. Niger J Clin Pract. 2015;18(4):573–6.
How to Cite This Article
Vancouver
Pagare J, Garad IM, Kale GN. Unveiling acute myeloid leukemia through gingival enlargement: A case report [Internet]. J Dent Panacea. 2025 [cited 2025 Oct 02];7(2):116-120. Available from: https://doi.org/10.18231/j.jdp.2025.025
APA
Pagare, J., Garad, I. M., Kale, G. N. (2025). Unveiling acute myeloid leukemia through gingival enlargement: A case report. J Dent Panacea, 7(2), 116-120. https://doi.org/10.18231/j.jdp.2025.025
MLA
Pagare, Jaishri, Garad, Ishwari Manikrao, Kale, Gayatri Namdeorao. "Unveiling acute myeloid leukemia through gingival enlargement: A case report." J Dent Panacea, vol. 7, no. 2, 2025, pp. 116-120. https://doi.org/10.18231/j.jdp.2025.025
Chicago
Pagare, J., Garad, I. M., Kale, G. N.. "Unveiling acute myeloid leukemia through gingival enlargement: A case report." J Dent Panacea 7, no. 2 (2025): 116-120. https://doi.org/10.18231/j.jdp.2025.025