González-Gualda E, Baker AG, Fruk L, Muñoz-Espín D. A guide to assessing cellular senescence in vitro and in vivo. FEBS J. 2021;288(1):56–80. https://doi:10.1111/febs.15570 [Google Scholar]
Chaib S, Tchkonia T, Kirkland JL. Cellular senescence and senolytics: the path to the clinic. Nat Med. 2022;28(8):1556–68. https://doi:10.1038/s41591-022-01923-y [Google Scholar]
Huang W, Hickson LJ, Eirin A, Kirkland JL, Lerman LO. Cellular senescence: the good, the bad and the unknown. Nat Rev Nephrol. 2022;18(10):611–27. https://doi:10.1038/s41581-022-00601-z [Google Scholar]
Albuquerque-Souza E, Crump KE, Rattanaprukskul K, Li Y, Shelling B, Xia-Juan X. et al. TLR9 mediates periodontal aging by fostering senescence and inflammaging. J Dent Res. 2022;101(13):1628–36. https://doi:10.1177/00220345221110108 [Google Scholar]
Albuquerque-Souza E, Shelling B, Jiang M, Xia XJ, Rattanaprukskul K, Sahingur SE. Fusobacterium nucleatum triggers senescence phenotype in gingival epithelial cells. Mol Oral Microbiol . 2024;9(2):29–39. https://doi:10.1111/omi.12432 [Google Scholar]
Zhu Y, Anastasiadis ZP, Espindola Netto JM, Evans T, Tchkonia T, Kirkland JL. Past and future directions for research on cellular senescence. Cold Spring Harb Perspect Med. 2024;14(2):a041205. https://doi:10.1101/cshperspect.a041205 [Google Scholar]
Rattanaprukskul K, Xia XJ, Jiang M, Albuquerque-Souza E, Bandyopadhyay D, Sahingur SE. Molecular signatures of senescence in periodontitis: clinical insights. J Dent Res. 2024;103(8):800–8. https://doi:10.1101/cshperspect.a041205 [Google Scholar]
Gonzales MM, Garbarino VR, Kautz TF, Palavicini JP, Lopez- Cruzan M. et al. Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial. Nat Med. 2023;29(10):2481–8. https://doi:10.1038/s41591-023-02543-w [Google Scholar]
Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N. et al. The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell. 2015;14(4):644–58. https://doi:10.1111/acel.12344 [Google Scholar]
Mooney EC, Holden SE, Xia XJ, Li Y, Jiang M, Banson CN. et al. Quercetin preserves oral cavity health by mitigating inflammation and microbial dysbiosis. Front Immunol. 12:774273. https://doi:10.3389/fimmu.2021.774273 [Google Scholar]
×
How to Cite This Article
Vancouver
Ahuja A, Patel N. Antisenescence therapy: The next leap in periodontal medicine [Internet]. J Dent Panacea. 2025 [cited 2025 Oct 29];7(3):123-124. Available from: https://doi.org/10.18231/j.jdp.81236.1761640259
APA
Ahuja, A., Patel, N. (2025). Antisenescence therapy: The next leap in periodontal medicine. J Dent Panacea, 7(3), 123-124. https://doi.org/10.18231/j.jdp.81236.1761640259
MLA
Ahuja, Annapurna, Patel, Nayana. "Antisenescence therapy: The next leap in periodontal medicine." J Dent Panacea, vol. 7, no. 3, 2025, pp. 123-124. https://doi.org/10.18231/j.jdp.81236.1761640259
Chicago
Ahuja, A., Patel, N.. "Antisenescence therapy: The next leap in periodontal medicine." J Dent Panacea 7, no. 3 (2025): 123-124. https://doi.org/10.18231/j.jdp.81236.1761640259